Karlovy Vary Region (Czech: Karlovarský kraj) is an administrative unit (Czech: kraj) of the Czech Republic, located in the westernmost part of its historical region of Bohemia. It is named after its capital Karlovy Vary.

Districts of Karlovy Vary Region:

- Cheb District

- Karlovy Vary District

- Sokolov District

Cities and towns

• Karlovy Vary
• Aš
• Cheb
• Chodov
• Františkovy Lázně
• Jáchymov
• Kraslice
• Loket
• Luby u Chebu
• Mariánské Lázně
• Nejdek
• Ostrov
• Skalná
• Sokolov